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Gerardo G Mackenzie Selected Research

2-(4-isobutylphenyl)propionic acid 4-(diethoxyphosphoryloxy)butyl ester

1/2012Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system.
9/2011Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents.
6/2011Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models.

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Gerardo G Mackenzie Research Topics

Disease

31Neoplasms (Cancer)
01/2022 - 10/2006
15Pancreatic Neoplasms (Pancreatic Cancer)
01/2022 - 12/2011
6Carcinogenesis
01/2021 - 01/2008
6Colonic Neoplasms (Colon Cancer)
04/2013 - 10/2009
5Neuroblastoma
11/2015 - 01/2002
4Breast Neoplasms (Breast Cancer)
11/2018 - 09/2011
4Hodgkin Disease (Hodgkin's Disease)
01/2018 - 10/2006
3Inflammation (Inflammations)
11/2021 - 11/2009
3Lung Neoplasms (Lung Cancer)
10/2020 - 04/2013
2Dysbiosis
11/2021 - 01/2015
2Adenocarcinoma
09/2021 - 11/2019
2Colorectal Neoplasms (Colorectal Cancer)
01/2020 - 12/2016
2Glioblastoma (Glioblastoma Multiforme)
12/2019 - 04/2016
2Metaplasia
10/2017 - 07/2016
1Cachexia
09/2021
1Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
11/2019
1Neoplasm Metastasis (Metastasis)
08/2019
1Lymphatic Metastasis
02/2019
1Papillary Thyroid Cancer
02/2019
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2019
1Ovarian Neoplasms (Ovarian Cancer)
01/2019
1Hypoxia (Hypoxemia)
11/2018
1Kidney Neoplasms (Kidney Cancer)
01/2017
1Hypertension (High Blood Pressure)
01/2017
1Pancreatitis
07/2016

Drug/Important Bio-Agent (IBA)

8Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2022 - 03/2009
7GemcitabineFDA Link
01/2022 - 01/2016
7Sulindac (Copal)FDA LinkGeneric
08/2013 - 10/2010
7NF-kappa B (NF-kB)IBA
11/2009 - 09/2002
6ZincIBA
11/2015 - 01/2002
5Pharmaceutical PreparationsIBA
01/2022 - 07/2008
5Valproic Acid (Depakote)FDA LinkGeneric
01/2020 - 01/2013
5Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
12/2011 - 01/2008
4TeaIBA
10/2019 - 05/2002
3Irinotecan (Camptosar)FDA LinkGeneric
01/2022 - 09/2011
3Antineoplastic Agents (Antineoplastics)IBA
11/2021 - 12/2011
3epigallocatechin gallate (epigallocatechin-3-gallate)IBA
10/2019 - 11/2018
3Ibuprofen (Motrin)FDA LinkGeneric
04/2016 - 06/2011
32-(4-isobutylphenyl)propionic acid 4-(diethoxyphosphoryloxy)butyl esterIBA
01/2012 - 06/2011
3Eflornithine (Ornidyl)FDA Link
07/2011 - 10/2010
3Transcription Factors (Transcription Factor)IBA
11/2009 - 01/2006
2Drug CombinationsIBA
01/2022 - 07/2011
2130-nm albumin-bound paclitaxelIBA
01/2022 - 11/2019
2Fluorouracil (Carac)FDA LinkGeneric
10/2020 - 09/2011
2ErbB Receptors (EGF Receptor)IBA
01/2020 - 08/2013
2MDC-1112IBA
01/2020 - 12/2019
2STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
12/2019 - 10/2013
2Paclitaxel (Taxol)FDA LinkGeneric
11/2019 - 09/2011
2PolyphenolsIBA
10/2019 - 11/2018
2Glucose (Dextrose)FDA LinkGeneric
10/2019 - 11/2018
2Ethylene Glycol (Monoethylene Glycol)IBA
12/2018 - 10/2017
2CurcuminIBA
01/2018 - 07/2008
2EstersIBA
06/2011 - 03/2009
2nitroxy-butyl-acetylsalicylic acidIBA
10/2009 - 01/2008
1Therapeutic UsesIBA
01/2022
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
11/2021
1Hyaluronic Acid (Hyaluronan)IBA
10/2021
1Complement System Proteins (Complement)IBA
09/2021
1Phosphotransferases (Kinase)IBA
01/2021
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
01/2021
1Fatty Acids (Saturated Fatty Acids)IBA
01/2021
1Unsaturated FatsIBA
01/2021
1Dietary Fats (Dietary Fat)IBA
01/2021
1Doxorubicin (Adriamycin)FDA LinkGeneric
10/2020
1LipidsIBA
01/2020
1Proanthocyanidins (Procyanidins)IBA
01/2020
1Serine (L-Serine)FDA Link
12/2019
1Taxoids (Taxanes)IBA
11/2019
1MicroRNAs (MicroRNA)IBA
11/2019
1Albumin-Bound PaclitaxelFDA Link
11/2019
1Nucleic AcidsIBA
11/2019
1RNA (Ribonucleic Acid)IBA
11/2019
1AntigensIBA
02/2019
1squamous cell carcinoma-related antigenIBA
02/2019
1Acetaminophen (Paracetamol)FDA LinkGeneric
01/2019
1antineoplaston A10 (A 10)IBA
01/2019
1Analgesics (Analgesic Drugs)IBA
01/2019
1AcidsIBA
12/2018
1Caspase 3 (Caspase-3)IBA
11/2018
1Caspase 8 (Caspase-8)IBA
11/2018
1Caspase 9IBA
11/2018
1Lactic Acid (Lactate)FDA LinkGeneric
11/2018
1Annexin A5IBA
11/2018
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2018
1EnzymesIBA
11/2018
1Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
11/2018
11,7- bis(4- hydroxyphenyl)- 4- N- phenylaminocarbonylhepta- 1,6- dien- 3,5- dioneIBA
01/2018
1Lipid NanoparticlesIBA
01/2018
1Proteins (Proteins, Gene)FDA Link
01/2018
1poly(lactide) (polylactic acid)IBA
10/2017
1poly(lactic acid-ethylene glycol)IBA
10/2017
1MineralocorticoidsIBA
01/2017
1AldosteroneIBA
01/2017
1procyanidinIBA
12/2016
1CeruletideIBA
07/2016
1AmidesIBA
04/2016

Therapy/Procedure

6Therapeutics
09/2021 - 04/2008
4Drug Therapy (Chemotherapy)
11/2019 - 11/2010
1Ketogenic Diet
09/2021
1Injections
07/2016